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ObjectiveTo investigate the clinical difference of ondansetron,metoclopramide and haloperidol in the prevention of postoperative nausea and vomiting after neurosurgery.MethodsNinety patients with neurosurgery were divided by random digits table method into four groups:control group ( 18 cases ) treated with 10 ml 0.9％ sodium chloride ;ondansetron group(24cases ) received ondansetron 4 mg;metoclopramide group (24 cases) with metoclopramide 10 mg and haioperidol group (24 cases) with haloperidol 2.5 mg.The efficacy and adverse reaction were compared among four groups.Results Compared with control group,ondansetron,metoclopramide and haloperidol could obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,the difference had statistical significance (P＜ 0.05).Total effective rate of ondansetron group [79.2％( 19/24)] was significantly higher than that of metoclopramide group [ 58.3％ ( 14/24 ) ] and haloperidol group [ 54.2％ ( 13/24 ) ] (P ＜ 0.05 ).And total effective rate of metoclopramide group and haloperidol group had no significant difference (P ＞ 0.05 ).The occurrence rate of adverse reaction of metoclopramide group [ 16.7％(4/24)] had no statistical significance compared with that of ondansetron group[8.3％(2/24)] and haloperidol group[ 12.5％(3/24)] (P ＞ 0.05).ConclusionsOndansetron,metoclopramide and haloperidol can obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,and the effect of ondansetron is significantly better than that of metoclopramide and haloperidol.Therefore,it is necessary to use drugs for preventing postoperative nausea and vomiting for patients during neurosurgery.
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Objective To observe the clinical curative effect of selective bronchial arterial embolization for severe hemoptysis.Methods Thirty-eight hospitalized patients with severe hemoptysis was enrolled in this study.Of which 31 patients were recurrent hemoptysis,27 patients were with bronchiectasis,4 patients were with bronchial lung cysts,4 patients had unknown causes,3 patients were with tuberculosis.All patients were diagnosed by chest imaging examination,fiber bronchoscopy,bronchial arteriography,and they were all treated by selective bronchial arterial embolization.Results The most times of embolization was 3,and bronchial arterial imaging were performed for vascular malformation.After having bronchial arterial embolization,35 patients were immediately released of bleeding.Postoperative 24 h,8 patients had hemoptysis again,of which 1 case was performed with conservative treatment and subsequently had pneumonectomy,5 patients had effective conservative treatment,2 cases were performed embolization again after failed conservative treatments.Hemoptysis completely disappeared within 1 week.The total effective rate was 97.4％(37/38).Patients were followed up for 1 year,of which 13 patients relapsed again,11 patients'annual and each time's quantity of hemoptysis reduced 50％.Two patients had pneumonectomy after a number of embolization.The total effective rate was 94.7％ (36/38).After treatment,3 patients had mild chest pain in short time,2 patients had shoulder pain,3 patients had chest tightness,and 3 patients had subcutaneous passive congestion.After being treated for short-term,these symptoms disappeared eventually.Conclusion Selective bronchial arterial embolization for the treatment of acute or recurrent severe hemoptysis is very effective,and can avoid the risk of surgery.It is effective for recurrent cases and worthy of clinical application.
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ObjectiveTo investigate the effect of nursing intervention on sleep quality of patients after cardiac intervention. Methods140 patients undergoing cardiac interventional surgery in our hospital from January 2010 to January 2011 were chosen as the research object.They were divided into the observation group and the control group in accordance with the principle of randomization with 70 cases in each group.The control group was treated with conventional methods of nursing care of cardiology.The observation group was given with sleep- related nursing interventions on the basis of the routine care.The sleep quality score (PSQI)24 h and 1 week,2 weeks postoperation and treatment compliance 2 weeks postoperation were compared between the two groups. ResultsThe study showed that the PSQI score 24h postoperation showed no significant difference,but 1 week and 2 weeks after the operation,the score of the observation group was significantly lower than the control group.The full compliance rate in the observation group was significantly higher than the control group.The non-full compliance rate was significantly lower than the control group,the differences were statistically significantConclusionsNursing intervention can improve treatment compliance of patients,improve sleep quality of patients after cardiac intervention.It is conducive to the rehabilitation of patients and is worthy of clinical application.
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ObjectiveTo explore the expression of Cyclooxygenase-2-specific(COX-2) in renal cell carcinoma and its relationship with angiogenesis.MethodsThe expression of COX-2,VEGF and bFGF in renal cell carcinoma specimens(85 cases) and adjacent normal tissue samples(48 cases) was measured by immunohistochemistry.Microvessel density (MVD) was evaluated by immunohistochemistry using a monoclonal antibody against CD34.ResultsThe positive expression rates of COX-2,VEGF and bFGF in adjacent normal tissue were 16.7％,20.8％,22.9％,and 77.6％,80.0％,74.1％ in renal cell carcinoma,respectively,the difference,were significant ( all P ＜0.01 ).MVD was (55.47 + 18.47 ) Counts/field in renal cell carcinoma,and ( 20.42 ± 8.72) Counts/field in adjacent normal tissue,the difference was significant( P ＜ 0.01 ).MVD in renal cell carcinoma which was positive expressed COX-2,VEGF,bFGF was higher than renal cell carcinoma which was negative expressed COX-2,VEGF,bFGF,the difference was significantly statistical( P ＜ 0.05 or P ＜0.01 ).COX-2 expression and VEGF,bFGF in renal cell carcinoma expression was positively correlated( P ＜0.01 ).Conclusion COX-2 expression was elevated in renal cell carcinoma,and it was related closely with renal cell carcinoma angiogenesis.